Journal article
Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization
CB Haas, H Chen, T Harrison, S Fan, M Gago-Dominguez, JE Castelao, MK Bolla, Q Wang, J Dennis, K Michailidou, AM Dunning, DF Easton, AC Antoniou, P Hall, K Czene, IL Andrulis, AM Mulligan, RL Milne, PA Fasching, L Haeberle Show all
Breast Cancer Research and Treatment | SPRINGER | Published : 2024
Abstract
Purpose: Mammographic density phenotypes, adjusted for age and body mass index (BMI), are strong predictors of breast cancer risk. BMI is associated with mammographic density measures, but the role of circulating sex hormone concentrations is less clear. We investigated the relationship between BMI, circulating sex hormone concentrations, and mammographic density phenotypes using Mendelian randomization (MR). Methods: We applied two-sample MR approaches to assess the association between genetically predicted circulating concentrations of sex hormones [estradiol, testosterone, sex hormone-binding globulin (SHBG)], BMI, and mammographic density phenotypes (dense and non-dense area). We created..
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Grants
Awarded by National Breast Cancer Foundation
Funding Acknowledgements
We thank all the individuals who took part in these studies and all the researchers, clinicians, technicians, and administrative staff who have enabled this work to be carried out.